In a recent study by our group, increased activity of genes associated with the NLRP3 inflammasome (CASP1, NLRP3, PYCARD, IL1B, IL1RN), as well as increased levels of IL-1-family cytokines (IL-1 receptor antagonist (IL1Ra), IL-18), were found in a transdiagnostic cohort with low-functional individuals with mental disorders (26). The gene discussed is IL1RN; the disease is psychiatric disorder.