In EphA2 knockout (–/– or KO) mouse lenses, mild nuclear cataracts were observed along with disrupted actin cytoskeleton, cell shape and organization of equatorial epithelial cells (Cheng et al., 2013), and misaligned and disorganized fiber cells (Jun et al., 2009; Cheng and Gong, 2011; Shi et al., 2012; Cheng et al., 2013; Zhou and Shiels, 2018). This evidence concerns the gene EPHA2 and nuclear cataract.