While the mechanism for cataracts in humans with EphA2 mutations remain unknown (Shiels et al., 2008; Tan et al., 2011; Masoodi et al., 2012; Sundaresan et al., 2012), changes in ion/fluid homeostasis due to disruption of connexins (GJs) or aquaporins (water channels) can lead to nuclear cataracts (Gong et al., 1998; White et al., 1998; Rong et al., 2002; Wang et al., 2009; Gao et al., 2013; Kumari et al., 2017). This evidence concerns the gene EPHA2 and nuclear cataract.