The levels of inflammatory circulating factors, such as soluble tumor necrosis factor receptors (sTNF-Rs), soluble intercellular adhesion molecule-1 (sICAM-1), interleukine (IL)-6, lipopolysaccharide binding protein (LBP), and C-reactive protein (CRP) are associated with weight loss in patients with non-small-cell lung cancer (NSCLC) (Staal-van den Brekel et al., 1995). The gene discussed is ICAM1; the disease is non-small cell lung carcinoma.