Activation of Akt, which is linked to cardiac hypertrophy in cardiomyocytes, is maintaining a high glucose supply in cancer cells by upregulating Glucose transporter 1(GLUT-1) and hexokinase-1 (HK-1) (Barthel et al., 1999; Rathmell et al., 2003; Majewski et al., 2004). The gene discussed is HK1; the disease is cancer.