SIRT6 stimulates fatty acid oxidation through activation of PPAR-gamma; thus, SIRT6 deficiency may worsen the course of non-alcoholic steatohepatitis (NASH) in mice (Kim et al., 2010; Naiman et al., 2019; Zhong et al., 2020). The gene discussed is PPARG; the disease is metabolic dysfunction-associated steatohepatitis.