SIRT1 expression falls in heart muscle cells during ischemia, while in SIRT1-overexpressing mice, heart muscle condition is more rapidly brought back to normal after ischemia, which can be related to SIRT1-mediated activation of MnSOD, Trx-1, and Bcl-xL, as well as SIRT1-dependent inhibition of Bax protein, mediated by FoxOs (Hsu et al., 2010). This evidence concerns the gene SIRT1 and ischemia.