In addition, Nod2 was reported to mediate an alleviative effect on dextran sulphate sodium (DSS)-induced colitis mice models via suppressing the gram-positive bacteria invasion and damage, while knocking out Nod2 abolished such effects (Jamontt et al., 2013; Jing et al., 2014; Luo et al., 2021b). The gene discussed is NOD2; the disease is colitis.