Of particular interest, Wnt-1 induced secreted protein-2 (WISP2/CCN5), which is involved in inflammation response and autoimmune disease (Tanaka et al., 2005; Macdonald et al., 2021), achieved the highest correlation coefficient (Rs = 0.81, p = 2.82e-5; Figure 2E). This evidence concerns the gene CCN5 and autoimmune disease.