Studies have reported associations of irAEs with the recruitment of CD14+CD16+ monocytes (Curry et al., 2019), the presence of eosinophilia (Kizawa et al., 2019), increased neutrophil/lymphocyte ratio (NLR) (Drobni et al., 2020), as well as NK cell-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) reactions (Kelly et al., 2018). This evidence concerns the gene CD14 and Increased total eosinophil count.