MTOR and Autoimmunity: Similar to mTOR signaling, the JAK/STAT pathway has been implicated in the pathogenesis of autoimmune states and irAEs (Esfahani et al., 2020), and the inhibition of JAK/STAT signaling has led to remarkable remissions in the setting of autoimmune disorders (Lee et al., 2014; Sandborn et al., 2017).