TFEB and Sepsis: Although there has been no direct report relating to TFEB and immunosuppression during sepsis, existing studies have demonstrated that TFEB intensifies immune responses by promoting antigen presentation in dendritic cells (Samie and Cresswell, 2015), resetting suppressive tumor-associated macrophages towards the M1 phenotype (Chen et al., 2018), reversing B cell senescence (Zhang et al., 2019), and by enhancing T cell immunity (Jin et al., 2021).