AKT1 and multiple sclerosis: In previous studies, miR-379-5p has been reported to be associated with autoimmune diseases of the central nervous system, multiple sclerosis, and its target genes are associated with cell death and inflammation, and miR-1296-5p inhibits liver cancer metastasis through the PI3K/Akt pathway and is downregulated in breast cancer (Xu et al., 2017; Baulina et al., 2018).