ANIT-induced CLD model mice treated with 25 mpk PTE showed only slightly upregulated FXR expression, whereas the 50 and 100 mpk treatments produced significantly increased FXR expression; however, FXR expression was lower in the 100 mpk PTE treatment than in the 50 mpk treatment. This evidence concerns the gene NR1H4 and congenital secretory chloride diarrhea 1.