Consistent with this, when SIRT1 was absent from BMDMs, no significant change in expression of inflammatory factors (Ccl2, TNF-α, Ccr2, and IL-1β) was observed after PTE treatment of DDC-induced CLD model mice (Figure 7G); however, FXR protein levels in the liver were decreased (Figure 7I). The gene discussed is NR1H4; the disease is congenital secretory chloride diarrhea 1.