The expression of LOX-1 is low under normal physiological conditions, but inflammatory modulators, including Ox-LDL, LPS, mitochondrial ROS, angiotensin II, sheer stress, pro-inflammatory cytokines, AGEs, and conditions such as high blood pressure, dyslipidemia, and diabetes mellitus, upregulate LOX-1 in AS (Kattoor et al., 2019). Here, OLR1 is linked to diabetes mellitus.