The similar tumor-inhibition effects of ALT, accompanied by apoptosis promotion and growth depression, could also be observed in osteosarcoma (Zhang Y. et al., 2020), esophageal cancer (Wang Z. et al., 2021), multiple myeloma (Yao et al., 2015), etc. The above studies explore the underlying molecular mechanism of the biological activity of ALT, contributing to the application of ALT as a promising chemotherapeutic candidate for different kinds of cancers. This evidence concerns the gene GPT and esophageal cancer.