GPT and lung adenocarcinoma: It has also been found that ALT could significantly enhance the anticancer effects of chemotherapy drug gemcitabine on lung adenocarcinoma cells A549 and lung squamous carcinoma cells NCI-H520 cells through inhibiting the activation of AKT/glycogen synthase kinase (GSK) 3β and endoplasmic reticulum (ER) stress pathways (Wang J. et al., 2019).