It has been found that ALT effectively induces cell apoptosis in both lung squamous carcinoma cells (SK-MES-1) and lung adenocarcinoma cells (NCI-H1299 and Anip973) and the cytotoxic influence of ALT is closely related to the improved treatment efficacy and prognosis of patients with lung cancer (Zhao et al., 2015; Liu et al., 2019). The gene discussed is GPT; the disease is lung cancer.