Besides, ALT impairs the angiogenesis and tumor growth by down-regulating vascular endothelial growth factor receptor 2 (VEGFR2) phosphorylation level and its downstream protein kinases, including phospholipase C gamma 1 (PLCγ1), protein tyrosine kinase 2 (FAK), SRC, and AKT (Liu Y. R. et al., 2018). This evidence concerns the gene KDR and neoplasm.