Of the expression of many m6A regulatory genes, including writers (METTL3, METTL14, WTAP, ZC3H13 and RBM15), erasers (ALKBH5 and FTO), and readers (YTHDF1, YTHDF2, YTHDF3, YTHDC1, IGF2BP1 and IGF2BP3) were found to be significantly increased in HNSCC tissues (Feng et al., 2021; Paramasivam et al., 2021). The gene discussed is METTL3; the disease is head and neck squamous cell carcinoma.