IGFBP7 transcripts are highly edited in the normal epidermis, while this editing is significantly reduced in basal cell and squamous cell carcinomas (Hochberg et al., 2013); 4) A-to-I is regulated by the ADAR enzyme RNA editing, thereby regulating the editing level of oncogenes and regulating the development of cancer (Qiao et al., 2014; Chen et al., 2017c; Chen et al., 2017d; Dong et al., 2018; Caponio et al., 2019; Yu et al., 2019). This evidence concerns the gene IGFBP7 and squamous cell carcinoma.