lincRNA-p21 was found by Zhang et al. to inhibit the cell cycle and proliferation of primary HSCs by enhancing p21 (Zheng et al., 2015), while Tu et al. found a significant increase in hepatocyte lincRNA-p21 expression during hepatic fibrosis (Tu et al., 2017). The gene discussed is CDKN1A; the disease is Hepatic fibrosis.