USP4 and Hepatic fibrosis: They demonstrated that the maintenance of USP4 levels could be mediated by H19 as ceRNA spongy miR-148a hair, and this evidence suggests that H19 may be a promising target for the treatment of liver fibrosis through the novel H19/miR-148a/USP4 axis that can promote liver fibrosis in HSC and hepatocytes (Zhu et al., 2019).