The NF-κB signaling pathway, an important transcription factor for many inflammatory mediators and cytokines, remains a dormant molecule in the cytoplasm by binding tightly to IκB inhibitor proteins (Inoue et al., 1992; Yang et al., 2012), and phosphorylation of IκB by IκB kinase (IKK) upon stimulation separates IκB from NF-κB leading to translocation and activation of NF-κB, a process reported to be involved in the formation and progression of liver fibrosis (Luedde and Schwabe, 2011; Wang T. et al., 2019; Zhang K. et al., 2020; Zhao et al., 2020). This evidence concerns the gene NFKB1 and Hepatic fibrosis.