And Ye et al. further identified that downregulation of NEAT1 could limit the inflammatory response and liver fibrosis in ASH mice by reducing suppressor of cytokine signaling 2 (SOCS2) (Ye et al., 2020), which is a feedback inhibitor of the growth hormone/insulin-like growth factor axis (Monti-Rocha et al., 2018). This evidence concerns the gene SOCS2 and Hepatic fibrosis.