Overall survival (OS), distant metastasis (DM), lymph node metastasis (LNM), and tumor staging of human tumors have been extensively studied and determined to be closely associated with HOTTIP expression, suggesting that HOTTIP expression may influence the prognosis and metastasis of several human cancers (Broerse and Crassini, 1984; Quagliata et al., 2014). The gene discussed is HOTTIP; the disease is cancer.