Lentivirus-mediated knockdown of lncRNA LFAR1 resulted in decreased expression of Notch2, Notch 3, Hes1, and Hey2 while suppressing CCl4-and BDL-induced upregulation of these genes, and this evidence suggests that lncRNA LFAR1 promotes processes such as liver fibrosis and HSC activation through activation of the Notch signaling pathway as well as acting as a Notch signaling pathway provides new insights to elucidate the molecular mechanisms of liver fibrosis (Zhang K. et al., 2017). Here, HES1 is linked to Hepatic fibrosis.