The regulatory role of lncRNAs in liver fibrosis via the Notch signaling pathway was recently reported, and protein and mRNA levels of Notch signaling-related molecules and target genes Notch2, Notch3, and Hes1 were reduced in HSCs with lncRNA LFAR1 downregulation and increased in HSCs with lncRNA LFAR1 overexpression (Zhang K. et al., 2017). This evidence concerns the gene HES1 and Hepatic fibrosis.