The most widely studied epigenetic modification, DNA methylation and its relevance to the pathogenesis of liver fibrosis have been well established experimentally (Benetatos et al., 2008; Li et al., 2010), and previous studies have suggested a role for DNA methylation in the deletion of MEG3 expression in tumors (Zhao et al., 2005; Benetatos et al., 2008). Here, MEG3 is linked to Hepatic fibrosis.