ANRIL binds to SUZ12 and cis-represses INK4β transcription; DBE-T cis-recruits Ash1L to the 4q35 region, catalyzing the establishment of activating chromatin modifications such as H3K36me2, which activates gene transcription in the 4q35 region, ultimately leading to FSHD (facioscapulohumeral muscular dystrophy) disease (Guttman et al., 2011; Kopp and Mendell, 2018; Riaz and Li, 2019). Here, SUZ12 is linked to facioscapulohumeral muscular dystrophy.