In a physical and functional interaction study with the liver fibrosis process, Yu et al. found that MALAT1 expression was significantly upregulated in fibrotic liver tissues and simultaneously activated HSCs (Yu et al., 2015a), while silencing MALAT1 suppressed the mRNA levels of α-SMA and Col.I and downregulated the protein levels of α-SMA and collagen type I in HSC respectively (Yu et al., 2015a). This evidence concerns the gene MALAT1 and Hepatic fibrosis.