He et al. revealed that MEG3 levels were significantly reduced in CCl4-induced liver fibrosis in mice and humans, while MSP was significantly reduced in CCl4-treated mouse liver tissue and human liver fibrosis tissue and TGF-β1-treated LX-2 cells where MEG3 promoter methylation was observed (He et al., 2014). Here, TGFB1 is linked to Hepatic fibrosis.