The findings of in silico molecular studies of ginger compounds interacting with various receptors or proteins (e.g. β3-AR, TRPV1) are promising for the design of novel drugs/inhibitors in combating obesity, diabetes, inflammation, nausea, vomiting, and SARS-CoV-2. Here, TRPV1 is linked to obesity due to melanocortin 4 receptor deficiency.