Current investigations have demonstrated that NLRP3 inflammasome–mediated cell death plays a critical role in the pathogenesis of multiple neurologic disorders (Heneka et al., 2018; Voet et al., 2019; Chen et al., 2021), as well as SCI (Jiang et al., 2017; Al Mamun et al., 2020). This evidence concerns the gene NLRP3 and nervous system disorder.