PPARGC1A and atrial fibrillation: Of note, pharmacological interventions targeting FAO regulators, AMPK and PGC1α (Yu et al., 2011; Liu et al., 2016; Bai et al., 2019; Deshmukh et al., 2021; Ostropolets et al., 2021), have been proved to reduce AF susceptibility, yet it is still unclear whether enhancing FAO alleviates AF.