CPT1B and obesity due to melanocortin 4 receptor deficiency: As expected, we proved that boosting FAO via LCA, a natural and biologically active micronutrient enhancing physiological FAO through CPT1B (Marcovina et al., 2013) and activation of AMPK signaling pathway (Figures 3, 6), can significantly reduce obesity-mediated AF propensity and the corresponding atrial remodeling (Figures 1, 2), thus better supports the efficiency of FAO promotion in the AF therapeutic approach.