As expected, we proved that boosting FAO via LCA, a natural and biologically active micronutrient enhancing physiological FAO through CPT1B (Marcovina et al., 2013) and activation of AMPK signaling pathway (Figures 3, 6), can significantly reduce obesity-mediated AF propensity and the corresponding atrial remodeling (Figures 1, 2), thus better supports the efficiency of FAO promotion in the AF therapeutic approach. Here, CPT1B is linked to atrial fibrillation.