The hypothesis suggested that the expression of BDNF can suppress epileptogenesis by a combined receptor-ligand pathway; and the TrkB binding to BDNF may be the most closely associated with epilepsy between its two corresponding receptor-ligand pathways (McNamara and Scharfman, 2012; Iughetti et al., 2018). The gene discussed is NTRK2; the disease is epilepsy.