Schroder and Tschopp (2010) showed that NOD-like receptor protein 3 (NLRP3) inflammasome is a molecular platform activated upon signs of cellular “danger” to trigger innate immune defenses through the maturation of pro-inflammatory cytokines such as interleukin (IL)-1β (Schroder and Tschopp, 2010; Jo et al., 2016). NLRP3 inflammasome-mediated inflammation takes part in neurologic diseases and can be activated by damaged mitochondria releasing ROS (Zhou et al., 2011; Alsaadi et al., 2021). The gene discussed is NLRP3; the disease is nervous system disorder.