For example, as one of the major components of CKI, sophoridine (KS18, DL = 0.25, Caco-2 = 1.13) displays antitumor, anti-allergic, anti-inflammatory, anti-arrhythmia, and antiviral properties, and affects the central nervous system (Han et al., 2009; Cuiping, 2010; Huang et al., 2014; Hu et al., 2016). The gene discussed is CHKA; the disease is cardiac arrhythmia.