Next, we constructed a comprehensive pathway (Figure 6), including the PI3K-Akt and cAMP signaling pathways, using CyKEGGParser to explore the synergetic mechanisms of Rhizoma Heterosmilacis and Radix Sophorae Flavescentis in the treatment of BC using CKI (Nersisyan et al., 2014). The gene discussed is AKT1; the disease is breast cancer.