Including TRPCs, TPRVs, TRPMs, TRPA1, TRPPs, and TRPMLs (Berridge et al., 2003; Rohacs, 2005; Monteith et al., 2007; Venkatachalam and Montell, 2007; Doherty et al., 2015; Vangeel and Voets, 2019), calcium homeostasis plays an important role in the occurrence, development, and metastasis of breast cancer, which is related to the response to metal ions (GO:0010038, FDR adjust p value = 9.17E-13). This evidence concerns the gene TRPA1 and breast carcinoma.