The expression levels of ATP6V1C2 (responsible for the vesicle acidification) and SLC18A2 (involved in the vesicle retrieved), were notably decreased to 0.03- and 0.0005-fold of control cells in the AD group, whereas their levels recovered to 2.10- and 0.47-fold of controls in AD_Pls group. The gene discussed is SLC18A2; the disease is Alzheimer disease.