AKT1 and Alzheimer disease: In summary, the alteration of transcriptional profiles in AD model and AD_Pls cells were investigated, the relevance of PI3K-Akt/mTOR and MAPK signaling pathway, autophagy, endocytosis, synaptic vesicle trafficking, autophagy and apoptosis to the pathogenesis of AD, as well as the potential role of seafood-derived Pls in relieving AD progression were analyzed.