Several literatures have reported a direct link between Pls deficiency and AD pathology, whereas the administration of Pls (1 mg/day) was effective to improve cognitive function of mild AD patients (Ginsberg et al., 1995; Wood et al., 2011; Fujino et al., 2017). The gene discussed is CTSC; the disease is hyperinsulinemic hypoglycemia, familial, 4.