AKT1 and early-onset autosomal dominant Alzheimer disease: Similarly, KEGG enrichment analysis indicated that “PI3K-Akt signaling pathway,” “Endocytosis,” “MAPK signaling pathway,” “Alzheimer disease,” “mTOR signaling pathway,” “protein processing in endoplasmic reticulum,” and “Autophagy” were the most represented pathways (Figure 2C).