PDS5B and Alzheimer disease: The MAGI2-AS3 expression was increased, and miR-374b-5p expression was declined in cell models exposed to Aβ25–35. The miR-374b-5p and MAGI2-AS3 serum levels in patients with AD showed a negative correlation; however, they were correlated with the severity of the disorder. MAGI2-AS3 reduction enhanced neuronal viability and attenuated neuroinflammation in AD. The neurotoxicity induced by Aβ is regulated by MAGI2-AS3/miR-374b-5p axis.