LINC01311 was downregulated, whereas miR-146a-5p was up-regulated in the AD cell model. LINC01311 up-regulation and hsa-miR-146a-5p downregulation led to the protection of the apoptosis induced by AB1-42, autophagy, decelerated proliferation, and accumulation of APP in cell models of AD. The gene discussed is APP; the disease is Alzheimer disease.