BACE1 and Alzheimer disease: Up-regulation of BACE1-AS and down-regulation of miR-214-3p was found in the cell models treated with Aβ and isoflurane, as well as plasma samples of AD patients. BACE1-AS sponged miR-214-3p and exacerbated isoflurane-induced neurotoxicity. Both BACE1-AS reduction and miR-214-3p up-regulation reversed the suppression of proliferation and the facilitation of apoptosis and autophagy of Aβ-treated induced by isoflurane.