BDNF and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: AntagoNATs effectively increased the expression of brain-derived neurotrophic factor (BDNF), a protein important in memory development (Modarresi et al., 2012), and the healthy allele of SCN1A, the haploinsufficiency of which triggers Dravet syndrome (Hsiao et al., 2016).