As indicated in previous reports, LncRNA LINC00094 (called BRD3OS as well) is involved in regulating BBB penetrability in the AD microenvironment by sponging miR-224-5p and miR-497-5p, and SH3GL2 mRNA is targeted by both of them (Zhu et al., 2019). This evidence concerns the gene SH3GL2 and Alzheimer disease.