Additionally, both local LHb chemogenetic inhibition (Nair et al., 2013; Tchenio et al., 2017), and direct pharmacological inhibition (Winter et al., 2011) and input-specific synaptic inhibition (Huang et al., 2019) have displayed efficacy as potential therapeutic options in rodent models of depression. The gene discussed is LHB; the disease is depressive symptom measurement.