Evidence from studies on autopsy brain tissues and on cellular and transgenic mouse models has revealed that SOCS proteins, especially SOCS1 and SOCS3, play a role in modulating microglial inflammatory signaling in AD (Cianciulli et al., 2017; Iwahara et al., 2017; Ruganzu et al., 2021). This evidence concerns the gene CISH and Alzheimer disease.