The association between epilepsy and hippocampal pathophysiology is also well established (de Curtis and Gnatkovsky, 2009; Cho, 2011; Berdichevsky et al., 2013; Roy et al., 2015; Mazumder et al., 2019), with some evidence for hippocampal seizure onset in patients with mutations in PI3K pathway (Jansen et al., 2015). Here, PIK3CA is linked to epilepsy.