ALS-associated mutations in SOD1 have been associated with increased ROS, with transgenic mice expressing G93A mutant human SOD1 showing oxidative damage to mitochondrial proteins and lipids (Mattiazzi et al., 2002; Vargas et al., 2011; Xiao et al., 2018; Chen et al., 2021; Méndez-López et al., 2021). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.