Several other ALS-associated mutations lie in genes that have also been associated with FTD, including ataxin-2 (ATXN2), cyclin F (CCNF), Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 10 (CHCHD10), chromosome 9 opening reading frame 72 (C9orf72), Dynactin (DCTN1), FUS, Optineurin (OPTN), TAR DNA binding protein (TARDBP or TDP-43), TANK-binding Kinase (TBK1), T cell-restricted intracellular antigen-1 (TIA1), Tubulin alpha 4A (TUBA4A) and valosin-containing protein (VCP) (Orr, 2011; Orsini et al., 2015; Greaves and Rohrer, 2019; Table 1). The gene discussed is OPTN; the disease is frontotemporal dementia.