Since exposure to MeHg: (1) hastens the onset of amyotrophic lateral sclerosis-like phenotype in SOD1-G93A mice by activating glutamate receptors (Johnson et al., 2011) and (2) determines neuronal cell death by increasing REST expression (Guida et al., 2017a,2018), we investigated the possible role of MeHg to accelerate death in NSC34 motor neuron-like cells transiently transfected with SOD1-G93A construct, via REST up-regulation. Here, REST is linked to amyotrophic lateral sclerosis.