By increasing access to information from large-scale imaging datasets and computing efficiency, FMFS may offer an efficient and effective screening tool to reveal the associations between Aβ/tau burden and hippocampal morphology across the dementia spectrum, and the features on ROIs could provide a means for screening individuals prior to more invasive Aβ/tau burden assessments that might determine their eligibility for interventional trials. Here, MAPT is linked to dementia.