Amyloid-β (Aβ) plaques and tau tangles are two specific protein pathological hallmarks of AD and are believed to induce neurodegeneration and structural brain atrophy consequentially observable from volumetric magnetic resonance imaging (MRI) scans (Jack et al., 2008; Selkoe and Hardy, 2016; Gordon et al., 2019; La Joie et al., 2020). Here, MAPT is linked to Alzheimer disease.