CALR and Splenomegaly: These patients have typical characteristics: AA or GA genotypes, high normal or above hemoglobin values (all were over 165 g/L), normal leukocyte and platelet counts, no splenomegaly, no canonical MPN mutations, i.e., Jak-2, calreticulin, MPL, and higher Hgb levels in GA and AA genotype groups compared to GG.