The Ca2+/calpain-mediated destructions of the important postsynaptic scaffold protein PSD95, of spectin/fodrin and of the NR2B subunit of NMDA-type glutamate receptors during the first hours after ischemic stroke received great attention, as they can be considered as being linked to the loss of synaptic connections [11–13]. Here, GRIN2B is linked to ischemic stroke.