COBL and ischemia: Serial section analyses of brains of Cobl KO mice [37] subjected to 30-minute MCAO showed that neither the ischemia-induced acute loss of Cobl we detected in the central brain segment and in the M1 nor the subsequent rapid restoration of normal Cobl levels in these brain parts had any influence on the survival of neurons within the infarct area in the striatum (S1F–S1H Fig).