The methylation status of other genes, including BMP3, SDC2, PHACTR3, SPG20, TFPI2, TMEFF2, KRAS, HPP1, SFRP2, MGMT, and WIF1, have also been investigated in fecal DNA for early detection of CRC [17,96,97,98,100]. The gene discussed is TMEFF2; the disease is colorectal carcinoma.