Knockdown of MYC in NUT carcinoma cell lines induced tumor cell differentiation (which is otherwise blocked by BRD4-NUT), while forced MYC expression reversed tumor cell differentiation that had been induced by BRD4-NUTM1 knockdown, demonstrating that MYC is necessary and sufficient for differentiation blockage [50]. The gene discussed is BRD4; the disease is nut midline carcinoma.