MYC and primary central nervous system lymphoma: For example, classic mutation profiles including MYD88 L265P and CD79B driving oncogenic toll-like receptor signaling, BCL2 and MYC rearrangements in nodal/systemic activated B-cell–like lymphoma-type DLBCL, nuclear factor kappa-β signaling pathway dysregulation, and copy number variations have been shown to play an oncogenic function in PCNSL [34].