The TT genotype of the REN rs12750834 SNP (OR: 2.8 [1.3–6.05], p = 0.008), and to a lesser extent the presence of the T allele (OR: 2.3 [1.2–4.48], p = 0.01), conferred a higher risk of BC (Table 2). This evidence concerns the gene REN and breast cancer.