Transcriptomic analyses of MPM have revealed that the immune-checkpoint protein programmed cell death ligand 1 (PD-L1) is significantly overexpressed in the sarcomatoid subtype [9], whereas V-domain Ig suppressor of T cell activation (VISTA) is significantly overexpressed in epithelioid [10] mesothelioma. This evidence concerns the gene CD274 and mesothelioma.