EGFR and adenocarcinoma: In fact, the IdyllaTM system is one of the rare solutions avoiding DNA extraction and allowing reliable EGFR genotyping directly from FFPE sample slides [20,25,33,34,35] in all patients with advanced NSCLC, mainly adenocarcinomas and squamous cell carcinomas in never-smokers, as in patients with stage IB to IIIA resected EGFR mutation-positive NSCLC [8].