To understand the functional role of SNHG3 in GC cells, we next knocked it down by transfecting MGC-803 and HGC-27 cells with sh-SNHG3 or control constructs, with both sh-SNHG3-2 and sh-SNHG3-3 being able to effectively inhibit the expression of this lncRNA (Figure 2A). The gene discussed is SNHG3; the disease is gastric cancer.