In summary, the in silico findings of our integrated bioinformatics analysis combining ceRNA network construction with WGCNA identified five differentially expressed lncRNAs (MIR4435-2HG, CASC9, LINC01980, STARD4-AS1 and MIR99AHG) with pronounced correlation with OS of HNSCC patients and one lncRNA (PART1) with a superior performance in discriminating HNSCC tissues from non-HNSCC normal tissues. The gene discussed is MIR99AHG; the disease is head and neck squamous cell carcinoma.