MAP3K5 and retinal degeneration: An example carried out by Liu Bei [12] is that CAR potently protected against retinal degeneration and inhibited both optic nerve injury (ONI)-induced nitric oxide synthase expression in the retina and activation of the apoptosis signal-regulated kinase 1 (ASK1) and p38 mitogen-activated protein kinase (MAPK) pathways, all of which suggested that CAR had neuroprotective and neuroregenerative effects.