A KEGG pathway integrated analysis of circRNAs–miRNAs–mRNAs revealed enrichment in the chemokine signaling pathway, leukocyte trans-endothelial migration, neuroactive ligand-receptor interaction, cytokine-cytokine receptor interaction, Rap1 signaling pathway, Chagas disease (American trypanosomiasis), B cell receptor signaling pathway, cholinergic synapse, oxytocin signaling pathway, amoebiasis, focal adhesion, Fc gamma R-mediated phagocytosis, NF-kappa B signaling pathway, melanogenesis and African trypanosomiasis (Figure 6b). Here, OXT is linked to Chagas disease.