In HCC, exosomal circ_0051443 derived from normal liver cells promotes cell apoptosis, arrests the cell cycle and inhibits the malignant phenotype of HCC cells by sponging miR‐331‐3p and upregulating BAK1, a cell death regulator that initiates mitochondria‐mediated cell apoptosis.63 Here, BAK1 is linked to hepatocellular carcinoma.