Further, our data revealed the reduced signalling activities of p‐Akt and p‐p44/42 MAPK, which are both the downstream of EGF/EGFR and VEGFA/VEGFR1 signalling pathways, suggesting that METTL1 knockdown decreased the mRNA translation of EGF/EGFR and VEGFA/VEGFR1 signalling pathway components, reduced the downstream signalling activities, and therefore inhibited proliferation and metastasis in HCC (Figure 4J). The gene discussed is EGF; the disease is hepatocellular carcinoma.