Our findings demonstrate that the cluster miR‐424(322)/503 regulates the fatty acid gene expression program in adipocytes, and we provide abundant evidence that this regulation is mainly mediated through the control of γ‐Synuclein (SNCG), a regulatory factor in fat cells that contributes to the development of obesity by promoting lipid metabolism and fat mass expansion.[20, 21]. Here, SNCG is linked to obesity due to melanocortin 4 receptor deficiency.