Tumor‐associated macrophages protect cancer cells through eliminating the anti‐tumor T cells by overexpressing PD‐L1, PD‐L2, CD80, and Siglec‐15 (Noy & Pollard, 2014; Mantovani et al, 2017; Wang et al, 2019). This evidence concerns the gene SIGLEC15 and neoplasm.