In order to further confirm that macrophages played a role mediating treatment effect of Carfilzomib on mutant EGFR‐driven lung cancers, we reconstituted the immune system of lethally irradiated TD mice with bone marrows of CD11B‐DTR transgenic mice, and then induced autochthonous lung cancers in these immune‐reconstituted mice by feeding them with Dox‐containing diet. Here, EGFR is linked to lung cancer.