In MPM from the catalogue of somatic mutations in cancer (COSMIC; Forbes et al, 2015), KRAS and TP53 mutation frequencies of 1–3% and 10–20%, respectively, were evident (Fig 1A; dataset available at https://cancer.sanger.ac.uk/cosmic/browse/tissue?wgs=off&sn=pleura&ss=all&hn=mesothelioma&sh=&in=t&src=tissue&all_data=n). The gene discussed is TP53; the disease is cancer.