Previous studies have found that in A. thaliana, bZIP60 mRNA is spliced by IRE1 upon ER stress and viral infections of TuMV, PVX, and PlAMV, which leads to the UPR (Deng et al., 2011; Gaguancela et al., 2016; Nagashima et al., 2011; Zhang et al., 2015). This evidence concerns the gene ERN1 and viral infectious disease.