BTK and Bruton-type agammaglobulinemia: However, RNA sequencing data generated from monocytes isolated from healthy donors and patients with X‐linked agammaglobulinemia (XLA) (inactive BTK) demonstrated differentially expressed novel lincRNAs that co‐located with genes related to ‘focal adhesion’ and ‘regulation of actin cytoskeleton’ (Mirsafian et al., 2017).