Moreover, hormonal and metabolic abnormalities characterizing early-onset androgenic alopecia (elevated levels of testosterone, dehydroepiandrosterone-sulfate [DHEA-S], luteinizing hormone [LH] and prolactin, decreased levels of follicle-stimulating hormone [FSH] and sex hormone-binding globulin, higher values of the free androgen index and the LH/FSH ratio, and insulin resistance) resemble those observed in women with polycystic ovary syndrome and their brothers [7–9]. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.