The area under the ROC curve (AUC) for the ability of netrin-1 level to independently predict a diagnosis of BPS/IC was 0.858 (95% CI: 0.788 to 0.929, P < 0.001), with better diagnostic efficacy than other clinical parameters including age, BMI, CRP, and NLR (Fig. 1B). Here, NTN1 is linked to Bartsocas-Papas syndrome 1.