Furthermore, Klopocki et al. [39] highlighted the role of PTHrP in human dental eruption, observing that two out of five families affected by E1 type brachydactyly (OMIM #113300) and carrying variants in the PTHLH gene, in addition to short stature and short fingers and metacarpals, also had multiple impacted teeth and/or PFE. This evidence concerns the gene PTHLH and brachydactyly.