Although GAK has not yet been confirmed as the gene driving association at this locus, this raises the possibility that there is a spectrum of risk associated with clathrin uncoating and Parkinson's, with loss of function in DNAJC6 causing a Mendelian form of parkinsonism, and more common (and subtle) variation in GAK associated with heightened risk of Parkinson's disease. The gene discussed is GAK; the disease is Parkinsonism.